Scientifically proven

Get to know the work teams and the results of their investigations.
Scroll down and find out how
icono-indicador-scroll

Longevity and well-being
as a life goal

In 2012 we began researching breathing and its role in cell regeneration and oxidative stress. We found that we could directly influence the body’s recovery process. Increase its energy, help to regenerate it and improve our well-being.

We develop technology with the utmost scientific rigor

We don’t know how to do it any other way. We subjected the first model to clinical trials and the results were very satisfactory. So much, that we ended up installing our technology in hospitals.

Maximum energy efficiency

The results continued to improve and more high-level institutions and companies joined our trials. Word soon spread and top-tier sports teams wanted our technology for their players. Real Madrid, the Spanish Football Federation, the Movistar Cycling team and Villarreal C.F. among others. It was clear, we had to open up our technology to everyone.

In 2019, we decided to launch our first personal use device with the goal of reaching everyone. Our bioavailable energy generator is focused on boosting the effects of sleep. The device is designed to fit into any bedroom.

ciencia-img-2

UNIOVI-BIOW CHAIR in exposome and oxidative stress

The cROS research group, belonging to the Health Research Institute of the Principality of Asturias (ISPA), led by Dr. Ana Coto, has scientifically demonstrated that Biow generates an optimal environment that favours cellular activity, improving mitochondrial capacity, protein synthesis and antioxidant activity.
The two keys on this study:

Increase in cellular energy production

energia-celular-tabla-1 english

Decrease in free radical
 generation

sistema-inmunologico-tabla-1 english

Biow and its effect on sleep

Study carried out in collaboration with the Clínica Universidad de Navarra

logo-clinica-universidad-navarra
The Biow system has shown positive effects on breathing and sleep quality. By improving lung function and cellular efficiency, its biologically active anions can contribute to healthier breathing. By being absorbed through the skin and mucous membranes, these anions can reduce exposure to air pollution. This improvement in cellular efficiency is shown to be beneficial for rest.

In collaboration with the Clínica Universidad de Navarra, Biow has carried out a study with patients with insomnia problems. We have worked on the basis of the Pittsburgh scale.

estudio-navarra-icono-1

100%

Patients with severe sleep problems improve their rest.
estudio-navarra-icono-2

79%

They reduce the time it takes for them to fall asleep.

estudio-navarra-icono-3

70%

Increased hours of sleep
estudio-navarra-icono-4

66%

Reduce their awakenings

UCAM-BIOW Chair
in Advanced Regenerative Medicine

La Universidad Católica de Murcia estudia la regeneración celular y los efectos del sistema desarrollado por Biow sobre la salud y el envejecimiento.En este proyecto participan, por parte de la UCAM, los investigadores postdoctorales Rubén Rabadán y Rubén Zapata, que desarrollan sus estudios en el laboratorio Dr. Juan Carlos Izpisúa Belmonte del UCAM HiTech.

This team has shown that Biow improves multiple parameters associated with aging in mice.
Results in elderly mice:

Liver lipoperoxidation

grafica-lipoxidacion-del-higado english

Cellular energy in the brain

Cellular energy in the muscles

These combined effects of the Biow in reducing free radical damage, increasing ATP (energy) production in the brain, and improving muscle energy capacity suggest a potential positive impact on cellular and tissue regeneration, pointing towards the promotion of an environment more conducive to tissue recovery and regeneration in the body.

Lipoperoxidation

Liver LPO

grafica-lpo-higado

Lipoperoxidation is a biochemical process in which lipids present in cell membranes are attacked by free radicals, resulting in the oxidation of these lipids. This can lead to cell dysfunction and a host of health problems, as cell membranes are critical to the integrity and proper functioning of cells.

Graphic legend: Young control mice (CON), young mice with BioW (BIOW), elderly control mice (AG CON), elderly mice with BioW (AG BIOW).

What we see in the graph is that Biow exerts a reduction of lipid damage by free radicals in young and old individuals.
Detailed explanation of the charts:

Young liver

Aged liver

  • A significant reduction in lipid damage from free radicals is observed in young and elderly individuals treated with BioW compared to those who did not receive the treatment (CON vs BIOW and AG vs AG BIOW).
  • This reduction in lipid damage is especially noticeable in the liver, which is the organ responsible for detoxification in the human body.
  • Although the results suggest a beneficial role, the exact mechanism behind this reduction is unclear. It is suggested that it could be due to an increase in the individual’s antioxidant defence or a direct action from the device.
  • It is noted that the antioxidant capacity of the individuals’ livers did not change during the study, suggesting that the reduction in lipoperoxidation observed is solely due to the direct action of the device.
Total Muscle Energy Capacity

ATP Muscle (aged)

grafica-atp-musculo-anciano

ATP is a crucial molecule for energy storage and transfer in cells.

The data obtained in the study of the ATP production capacity in the muscle of elderly mice have shown that the ion inducer developed within the BioW equipment is sufficient to significantly increase the energy capacity in elderly.

This graph highlights the relevance of maintaining mitochondrial capacity to maintain muscle activity in the lower limbs, which contributes significantly to delaying dependence in older people. It is highlighted that the equipment used in this research not only has a specific effect, but also affects the body as a whole. The relationship between fatigue in the elderly and the decrease in lung and cardiac capacity is highlighted, which impacts the uptake of muscle oxygen and the appearance of dependence. It is suggested that the observed improvement in ATP production in elderly muscles could be related to systemic improvement, including a possible influence of reduced environmental pollution. These results are critical to promoting healthy aging by reducing fatigue and preserving muscle mass, crucial aspects of maintaining independence in old age.

Impact of BioW Use on Metabolic and Molecular Markers in Elderly Mice:
Evidence for Metabolic Rejuvenation and Reduced Inflammation

Glucose

 

Glucose-6P

 

Citric Acid

 

Ribose-5P

 

Hexose-6P

 

grafica-hexose-6p

Glycerol-3P

 

Blood analysis of the mice showed a decrease in the levels of several components related to important metabolic processes, such as glycolysis, the pentose phosphate pathway, the Krebs cycle, and triglyceride biosynthesis (all of which are closely linked to energy production and storage).

These reduced levels resembled those found in young mice, as opposed to untreated elderly mice, which maintained higher levels. In addition, changes in molecular markers were detected in the blood. For example, phenylalanine, an amino acid associated with heart damage in old age, decreased after exposure to Biow in elderly mice, reaching levels similar to those in young mice. On the other hand, carnitine C:5, which facilitates the transport of fatty acids in the mitochondria, recovered after use of Biow, as did kinurenic acid, an inflammatory mediator associated with aging.

KYNA

 

grafica-kyna

Phenylalanine

 

Carnitine C:5

 

In liver tissue, changes in metabolic markers were also observed. A tendency for increased ATP was detected in animals treated with Biow, as well as a decrease in levels of kinurenic acid, a marker of inflammation. A reduction in short-chain carnitines was observed in the treated animals, which is curious since previous studies had described an increase in these carnitines in the liver during aging. A reversal in hippuric acid levels, associated with frailty in old age, was also observed after treatment with Biow.

In addition, treatment with Biow produced a significant change in S-adenosylmethionine, an important metabolite for the synthesis of DNA, RNA, and proteins, the levels of which decline with age. Treatment with Biow restored levels of this metabolite to levels found in young mice.

Citric Acid

 

KYNA

 

grafica-kyna

Phenylalanine

 

ATP

 

Blood tests from aged mice showed that Biow reduced the levels of certain elements related to energy production in the body, making them look younger. We found similar changes in blood markers and in the liver, where we saw improvements in metabolic health and inflammation. The use of Biow also appears to have reversed some signs of aging in exposed mice, such as decreased metabolic energy, inflammation, frailty, and altered biomolecule synthesis, suggesting its potential to help maintain health as we age.

*Kanurenic acid (KYNA): inflammatory marker.

Liver LPO

grafica-lpo-higado

ATP Brain (Aged)

grafica-atp-cerebro-anciano

ATP Muscle (Aged)

grafica-atp-musculo-anciano

The use of BioW shows a beneficial effect in reducing lipid damage by free radicals, especially in the liver, due to the direct action of the device. A significant decrease in lipid damage is observed in young and elderly individuals treated with BioW compared to those not treated. This finding is relevant given the importance of the liver in the detoxification of the human body. In addition, the increase in energy capacity in the muscles of elderly mice suggests a comprehensive effect of BioW equipment in preserving muscle activity, promoting healthy aging and independence in old age.